RESUMO
Abstract Objectives To compare the efficacy and safety of larotrectinib with those of infigratinib in adult glioma patients with tyrosine kinase alterations. Methods Patients received oral infigratinib 125 mg (IN cohort, n = 125) or oral larotrectinib (LB cohort, n = 105) until unacceptable toxicity or disease progression. Results Duration of treatment was longer in the LB cohort than in the IN cohort (8 [9.5-6.25] months vs. 5.5 [6-5.25] months, p < 0.0001). Patients with partial responses (p = 0.0424) and overall survival (p = 0.03) were higher in the IN cohort than those in the LB cohort. The number of patients with disease progression was higher in the LB cohort (p = 0.0015). All the patients reported diarrhea, fatigue, vomiting, constipation, and decreased appetite. Patients in the IN cohort reported hyperphosphatemia, hyperlipasemia, stomatitis, dry skin, alopecia, dyspepsia, onycholysis, palmar-plantar erythrodysesthesia, nail disorders, and dry eyes. Patients in the LB cohort reported upper respiratory tract infections, pyrexia, cough, anemia, bacterial/viral infections, conjunctivitis, urinary tract infections, headaches, ataxia, dizziness, and muscle tremors. A total of 30 (24 %) and 40 (38 %) patients from the IN and the LB cohorts died at the follow-up of 18 months (p = 0.03). Patients who received bevacizumab initial therapy had higher overall survival (p = 0.048). Conclusions Infigratinib has higher efficacy and overall survival than larotrectinib but has higher adverse effects in the management of both glioma and tyrosine kinase alterations after failure of initial therapies. Initial bevacizumab therapy is associated with a higher overall survival.
RESUMO
Objective To analyze the clinical efficacy of arthroscopic assisted surgery for tibial plateau fractures and discuss the characteristics of the treatment. Methods 60 patients were randomly divided into observation group and control group, 30 cases in each. The observation group was treated by limited reduction and internal fixation with knee arthroscopy, while the control group was treated with traditional open reduction and internal fixation. Among them, there were 18 cases of rupture of the free edge of the meniscus, including 11 cases of avulsion fracture of the tibial ligament of the anterior cruciate ligament and 9 cases of the rupture of the medial collateral ligament. At the end of the operation, the operation time and incision length of the two groups were observed and the two groups were followed up for 1 year after operation. The curative effect was evaluated according to the HSS functional standard of knee joint. Results After treatment, the operation time in observation group was (81.6 ± 21.7) min, which was significantly lower than that in control group (109.7 ± 31.6) min; the cut length of the observation group is shorter than the control group, two sets of contrasting differences, P < 0.05, statistically significant. Observe the incidence of postoperative complications of the group is 3.3％ in the control group incidence of complications after surgery for 20.0％, two sets of contrasting differences, P < 0.05; in terms of clinical, Observer Group of patients has a high rate of 96.7％, much better than the control group patients with 60.0％, two sets of contrasting differences, statistically significant, P < 0.05. Conclusion Arthroscopic assisted surgical treatment of tibial plateau fractures, to maximize patient cure rates, reduce the probability of complications and have a less traumatic, intuitive, reliable fixed reset features, and clinically to promote.